On November 14, 2024, 12 Institutes/Centers within NIH issued a Notice of Special Interest (NOSI) informing potential applicants of the NIH Climate Change and Health Initiative’s interest in supporting implementation science related to climate change and health. The NOSI encouraged applications that propose implementation studies to understand and address barriers and facilitators to the adoption, implementation, scale-up, and sustainment of effective interventions to prevent or mitigate the health effects of climate change in the United States and globally. The NOSI said it would apply to application due dates on or after February 5, 2025, and subsequent receipt dates through January 7, 2028. The NOSI noted that the 2022 Strategic Framework had called for health intervention research and implementation science that provides the evidence base to guide implementation of timely, effective strategies to prevent disease and disability and promote health.